Macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a functionally polymorphic genetic locus. MIF is a highly conserved 12.5 kDa secretory protein that is involved in numerous biological processes. The expression and secretion profile of MIF suggests that MIF to be ubiquitously and constitutively expressed in almost all mammalian cells and is vital for numerous physiological processes. MIF is a pleiotropic inflammatory cytokine important in the upstream regulation of both innate and adaptive immunological responses and has been implicated in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
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Macrophage migration inhibitory factor (MIF) Related Products (31)
Related Products (31)
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BMY-25551
0 ImagesCat. No.: HY-167880CAS No.: 105139-98-8BMY-25551 is a Mitomycin A (HY-130332) analogue that is 8 to 20 times more potent than Mitomycin C (HY-13316) in cytotoxicity to murine and human tumor cell lines. BMY-25551 can be utilized in cancer and hematologic depression research.
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MIF-IN-1
0 ImagesCat. No.: HY-144190CAS No.: 851095-20-0MIF-IN-1 (compound 14) is a potent macrophage migration inhibitory factor (MIF) inhibitor (pIC50=6.87).
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RGB097
0 ImagesCat. No.: HY-159086CAS No.: 3099108-75-2RGB097 is a potent D-dopachrome tautomerase (D-DT) inhibitor with an IC50 value of 0.5 µM. RGB097 has the potential for the research of cancer.
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MIF-IN-5
0 ImagesCat. No.: HY-146318CAS No.: 2582755-31-3MIF-IN-5 (compound 1d) is a potent and reversible macrophage migration inhibitory factor (MIF) competitive inhibitor with an IC50 of 4.8 μM and a Ki value of 3.3 μM, respectively.
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ISO-92
0 ImagesCat. No.: HY-123970CAS No.: 899433-49-9ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research.
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HTS05585
0 ImagesCat. No.: HY-174842CAS No.: 696643-14-8HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis.
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4-IPP (Standard)
0 ImagesCat. No.: HY-110063RCAS No.: 41270-96-6Synonyms: 4-Iodo-6-phenylpyrimidine (Standard)4-IPP (Standard) is the analytical standard of 4-IPP (HY-110063). This product is intended for research and analytical applications. 4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).
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ISO-1 (Standard)
0 ImagesSynonyms: MIF Antagonist (Standard)ISO-1 (Standard) is the analytical standard of ISO-1. This product is intended for research and analytical applications. ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
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Iguratimod (Standard)
0 ImagesSynonyms: T614 (Standard)Iguratimod (Standard) is the analytical standard of Iguratimod. This product is intended for research and analytical applications. Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
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BTZO-1 (Standard)
0 ImagesCat. No.: HY-110084RCAS No.: 99420-15-2BTZO-1 (Standard) is the analytical standard of BTZO-1 (HY-110084). This product is intended for research and analytical applications. BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
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(±)-CPSI-1306 (Standard)
0 ImagesCat. No.: HY-110095RCAS No.: 1309793-47-2(±)-CPSI-1306 (Standard) is the analytical standard of (±)-CPSI-1306 (HY-110095). This product is intended for research and analytical applications. (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
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